hrp0092t3 | Top 20 Poster | ESPE2019

Hypothalamus and Pituitary Gland Antibodies in Childhood-Onset Brain Tumors and Pituitary Dysfunction

Patti Giuseppa , Calandra Erika , De Bellis Annamaria , Gallizia Annalisa , Napoli Flavia , Crocco Marco , Bellastella Giuseppe , Maiorino Maria Ida , Luisa Garrè Maria , Parodi Stefano , Maghnie Mohamad , Di Iorgi Natascia

Background: Antipituitary (APA) and antihypothalamus antibodies (AHA) have not been investigated in children and adolescents with brain tumors.Patients and Methods: Sixty-three patients with craniopharyngioma, glioma and germinoma treated with surgery and/or chemotherapy and/or radiotherapy were evaluated at a median age of 13 years. Forty-one had MPHD, 6 had a single defect being GH the most common (65.1%), followed...

hrp0082p3-d1-815 | Growth | ESPE2014

Insulin Tolerance Test and GHRH Plus Arginine in the Reassessment of Pituitary Function at Adult Height Achievement

Di Iorgi Natascia , Salerno Maria Carolina , Cappa Marco , Loche Sandro , Radetti Giorgio , Capaldo Donatella , Napoli Flavia , Calcagno Annalisa , Allegri Anna Elsa Maria , Iovovich Ofelia Bianca , Noli Serena , Parodi Stefano , Maghnie Mohamad

Background: There is still need to define permanent GHD after adult height achievement in young adults with childhood-onset GHD (COGHD).Objective and hypothesis: To reassess GH response during transition.Method: We present the final data of 129 subjects (71M) recruited from a multicenter cross-sectional observational study, in whom anthropometrics, ITT (n=99), GHRH–arginine (n=122), IGF-1 evaluations were und...